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Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of <t>IGFBP3</t> and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
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Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of <t>IGFBP3</t> and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
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Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of <t>IGFBP3</t> and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
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Average 95 stars, based on 1 article reviews
anti igfbp3 - by Bioz Stars, 2026-03
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Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of IGFBP3 and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h

Journal: Journal of Translational Medicine

Article Title: Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma

doi: 10.1186/s12967-025-07606-9

Figure Lengend Snippet: Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of IGFBP3 and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h

Article Snippet: IGFBP3 specific siRNA was purchased from MedChemExpress (Cat. No. HY-RS06626, pre-designed siRNA).

Techniques: Quantitative RT-PCR, Biomarker Discovery, Gene Expression

IGFBP3 expression positively correlates with VEGFA and regulates meningioma cell viability and migration. (A–B) Correlation of IGFBP3 and NDRG1 expression with VEGFA in meningioma patients. ( C ) RT-qPCR validation of IGFBP3 across tumor grades and recurrent vs. non-recurrent cases. (D) Confirmation of IGFBP3 downregulation at the protein level upon IGFBP3 siRNA transfection via western blotting ( n = 2) ( E ) IGFBP3 depletion reduces meningioma cell viability. ( F-G ) Wound-healing assay showing reduced migration upon IGFBP3 silencing

Journal: Journal of Translational Medicine

Article Title: Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma

doi: 10.1186/s12967-025-07606-9

Figure Lengend Snippet: IGFBP3 expression positively correlates with VEGFA and regulates meningioma cell viability and migration. (A–B) Correlation of IGFBP3 and NDRG1 expression with VEGFA in meningioma patients. ( C ) RT-qPCR validation of IGFBP3 across tumor grades and recurrent vs. non-recurrent cases. (D) Confirmation of IGFBP3 downregulation at the protein level upon IGFBP3 siRNA transfection via western blotting ( n = 2) ( E ) IGFBP3 depletion reduces meningioma cell viability. ( F-G ) Wound-healing assay showing reduced migration upon IGFBP3 silencing

Article Snippet: IGFBP3 specific siRNA was purchased from MedChemExpress (Cat. No. HY-RS06626, pre-designed siRNA).

Techniques: Expressing, Migration, Quantitative RT-PCR, Biomarker Discovery, Transfection, Western Blot, Wound Healing Assay